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This part of the problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight naturally can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you need to err to the side of caution and allow the FDA do its job and demand some research be done so the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on their own medications. Researchers found that participants investing in this drug to get a year, lost weight within 4 weeks and have kept the extra weight off during the entire 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more efficient and safer. Combo-pilling could be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular is the fact that since right now there are no long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug can also raise blood pressure level and pulse rate, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not be used in patients with uncontrolled high blood pressure level, as well as by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. 'The intent on this bill is always to give police force and district attorneys something to address illicit drug use among expectant women through treatment programs," Tennessee governor Bill Haslam said.