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This part of the problem regulates reward responses in establishing food and sex, plus in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both after they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you need to err along the side of caution and allow the FDA do its job and demand some research be done in order that the public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on the medications. Researchers discovered that participants taking this drug for a year, lost excess weight within one month and have kept the load off through the 56 weeks in the study. Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which are made up of several active ingredient, which may make them more efficient and safer. Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular could be the fact that since right now there aren't any long term prescription diet pills that have been approved by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug also can raise blood pressure levels and heartrate, and shouldn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high blood pressure, and also by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. The course of recovery, even for those utilizing the medications, centers more about talk and less on pills because while drugs like acamprosate and naltrexone help change brain chemistry, they don't really change minds. Once you're taking away the alcohol, sometimes with all the successful usage of prescribed medicine, the minds still need work. Alcoholics who slip in recovery and non-alcoholics drink for essentially the same reason: It relieves social/physical/emotional tension. With alcoholics however, their are programmed differently genetically and answer drinking with additional drinking. So counseling or possibly a 12-step meeting helps those abstinent keep from utilizing the first drink. Recovery has very little to do with stopping the drinking and people successful in recovery admit they're success is based on learning or relearning the best way to manage life's tensions.